Her brother Richmond Arquette announced her death in a post on his Facebook page, reports.
He wrote: “Our brother Robert, who became our brother Alexis, who became our sister Alexis, who became our brother Alexis, passed this morning September 11, at am.
Next, Lynch created his own television series with Mark Frost, the popular murder mystery Twin Peaks (1990–1991).
He also created a cinematic prequel, Twin Peaks: Fire Walk with Me (1992), a road movie Wild at Heart (1990) and a family film The Straight Story (1999) in the same period.
'They're a very disrespected community.' Patricia first broke the news of Alexis' death from an illness in September last year, issuing a statement on behalf of the famous family on Richmond's Facebook page.'Alexis was born as Robert, our brother. But he came in as more than a sibling - he came as our great teacher,' the statement reads.
'As Alexis transitioned into being a woman, she taught us tolerance and acceptance.
They have their civil rights taken away,' she added.
After Eraserhead became a cult classic on the midnight movie circuit, Lynch was employed to direct a biographical film about a deformed man, Joseph Merrick, titled The Elephant Man (1980), from which he gained mainstream success.
He was then employed by the De Laurentiis Entertainment Group and proceeded to make two films: the science-fiction epic Dune (1984), which proved to be a critical and commercial failure, and then a neo-noir crime film Blue Velvet (1986), which stirred controversy over its violence but grew in critical reputation later on.
David Keith Lynch (born January 20, 1946) is an American director, screenwriter, producer, painter, musician, actor, and photographer.
He has been described by The Guardian as "the most important director of this era".
Roman Reigns for the Universal title at this year’s event. Kick-Off Show Kick-Off Show panel is Renee Young, David Otunga and Peter Rosenberg.